Reaktion #54342

Reaktionsgleichung

hydrogen

3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-1,2,5,6-tetrahydropyridine

ethanol

→

title compound

Ausbeute 62.0%

3-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]piperidine

Ausbeute 62.0%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 7.4 g
2. 2
   FiltrationThe reaction is filtered through diatomaceous earth
3. 3
   Sonstigeevaporated
4. 4
   SonstigeCrystallization of the residue from ether-pentane
5. 5
   Sonstigegave 4.6 g

Vorschrift

A mixture of 7.4 g. (24.5 mmoles) of 3-[4-(1,1-dimethylheptyl)-2-hydroxyphenyl]-1,2,5,6-tetrahydropyridine and 2.0 g. of 10% palladium-on-carbon in 150 ml. of ethanol and 75 ml. of ethyl acetate is stirred under one atmosphere of hydrogen for 2.5 hours. The reaction is filtered through diatomaceous earth and evaporated. Crystallization of the residue from ether-pentane gave 4.6 g. (62%) of the title compound.

Quelle