Reaktion #543362

Reaktionsgleichung

6-((2-(2-methyl-1,3-dioxolan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl)methyl)quinoline

Na2CO3

→

title compound

Ausbeute 75.7%

1-(7-(Quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)ethanone

Ausbeute 75.7%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   Trocknendried over Na2SO4
3. 3
   SonstigeThe solvent was removed in vacuo

Vorschrift

A solution of 6-((2-(2-methyl-1,3-dioxolan-2-yl)imidazo[1,2-b][1,2,4]triazin-7-yl)methyl)quinoline (130 mg, 0.37 mmol) in 3 N HCl (5 mL) was stirred at 90° C. for 0.5 h. The reaction mixture was cooled to room temperature, neutralized with saturated aqueous Na2CO3 solution, extracted with ethyl acetate, dried over Na2SO4. The solvent was removed in vacuo to afford 85 mg (75%) of the title compound as yellow solid. 1H-NMR (400 MHz, CDCl3) δ ppm 9.06 (s, 1H), 8.91 (d, 1H), 8.12 (t, 2H), 8.04 (s, 1H), 7.74-7.71 (m, 2H), 7.48-7.39 (m, 1H), 4.60 (s, 2H), 2.70 (s, 3H). LCMS (method B): [MH]+=304, tR=1.81 min.

Quelle