Reaktion #543127

Reaktionsgleichung

Diethyl ether

methyl (4-methoxybenzoyl)pyruvate

4-isoxazol-3-ylaniline

3-fluorobenzaldehyde

→

5-(3-fluorophenyl)-3-hydroxy-1-(4-isoxazol-3-ylphenyl)-4-(4-methoxybenzoyl)-1,5-dihydropyrrol-2-one

Ausbeute 34.0%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe precipitate was collected by filtration

Vorschrift

To a mixture of methyl (4-methoxybenzoyl)pyruvate (0.24 g, 1 mmol) and 4-isoxazol-3-ylaniline (0.16 g, 1 mmol) in dioxane (1 mL) was added 3-fluorobenzaldehyde (0.11 mL, 1 mmol). The mixture was stirred at r.t. for two days. Diethyl ether (3 mL) was then added to the mixture, and the precipitate was collected by filtration to give 5-(3-fluorophenyl)-3-hydroxy-1-(4-isoxazol-3-ylphenyl)-4-(4-methoxybenzoyl)-1,5-dihydropyrrol-2-one (0.16 g, 34%) as slightly yellow crystals.

Quelle