Reaktion #5431

ord-918dffba71544237accb80156ad6bdb6

Reaktionsgleichung

CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-Leu
C=O
formaldehyde
CC(C)C[C@H](N)C(=O)O
Leu
→
CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-Leu
CC(C)(C)OC(=O)N[C@@H](Cc1cc2ccccc2[nH]1)C(=O)O
Boc-Trp
CC(C)C[C@@H](C=O)NC(=O)OC(C)(C)C
Boc-Leu-CHO

Edukte

CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)O
Boc-Leu
C=O
formaldehyde
CC(C)C[C@H](N)C(=O)O
Leu

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Leu-psi -Tpi-BHA resin is made by reacting Boc-Leu-psi -Trp-BHA resin with formaldehyde in accordance with the procedures as follows: Boc-Leu-psi -Trp-BHA resin is obtained from 1.0 g BHA resin (0.9 m mode NH2 g) with coupling Boc-Trp and Boc-Leu-CHO successively by the method indicated in Operation I and Operation II. 10 ml. DMF containing 1% acetic acid is added to the above peptide resin and then reacted with 1 ml 10% formaldehyde at room temperature for 60 minutes and washed with DMF, MeOH and DCM.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05244883uspto-grants-1993_09