Reaktion #5430

Reaktionsgleichung

potassium hydroxide

4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide

→

5-tert-Butylaminocarbonyl-2-methylthiothiazole-4-carboxylic acid

Lösungsmittel

water

water ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed for 2 hours
2. 2
   SonstigeThe solvent mixture was then removed under reduced pressure
3. 3
   FiltrationThe precipitated product was filtered off
4. 4
   Sonstigedried

Vorschrift

0.82 g (14.6 mmol) of potassium hydroxide in 10 ml of water was added to a solution of 4.00 g (13.2 mmol) of 4-ethoxycarbonyl-2-methylthiothiazole-5-carboxylic acid-tert-butylamide in 50 ml of water/ethanol (2:1), and the mixture was refluxed for 2 hours. The solvent mixture was then removed under reduced pressure and the residue was taken up in 50 ml of water and acidified with concentrated hydrochloric acid. The precipitated product was filtered off and dried.

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