Reaktion #542530

Reaktionsgleichung

1,3,4,9-tetrahydro-indeno[2,1-b]pyridin-2-one

acetic acid

→

title compound

cis-1,3,4,4a,9,9a-hexahydro-indeno[2,1-b]pyridin-2-one

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst is then separated by filtration
2. 2
   Einengenthe filtrate is concentrated
3. 3
   SonstigeThe residue is triturated with tert-butyl methyl ether
4. 4
   Sonstigedried

Vorschrift

A mixture of 1,3,4,9-tetrahydro-indeno[2,1-b]pyridin-2-one (1.10 g), 10% palladium on carbon (0.15 g), acetic acid (0.75 mL), and methanol (20 mL) is shaken under hydrogen atmosphere (3 bar) at room temperature for 6 h. The catalyst is then separated by filtration and the filtrate is concentrated. The residue is triturated with tert-butyl methyl ether and dried to give the title compound as a colorless solid. Yield: 0.99 g (89% of theory); LC (method 1): tR=2.53 min; Mass spectrum (ESI+): m/z=188 [M+H]+.

Quelle