Reaktion #54248

Reaktionsgleichung

N-phenylethylenediamine

1-benzyl-4-piperidone

sodium cyanoborohydride

→

1-benzyl-4-(2-phenylaminoethylamino)-piperidine

Lösungsmittel

methanol

methanol

hydrogen chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter 72 hours the mixture is filtered
2. 2
   workup.DISSOLUTIONthe residue dissolved in water
3. 3
   ExtraktionIt is extracted with methylene chloride
4. 4
   Sonstigedried
5. 5
   Sonstigeevaporated

Vorschrift

To the solution of 12.6 g of N-phenylethylenediamine in 200 ml of methanol, 50 ml of 4.1 N ethanolic hydrogen chloride are added dropwise followed by 18.9 g of 1-benzyl-4-piperidone in 100 ml of methanol. Then, 9.45 g sodium cyanoborohydride are added in portions while stirring at room temperature. After 72 hours the mixture is filtered, the residue dissolved in water and the solution made basic with 12.5% aqueous sodium hydroxide. It is extracted with methylene chloride, dried and evaporated to yield the 1-benzyl-4-(2-phenylaminoethylamino)-piperidine.

Quelle