Reaktion #54239

Reaktionsgleichung

water

2,4'-Dichloroacetophenone

1,2,4-triazole

Triethylamine

→

2-(1,2,4-triazol-1-yl)-4'-chloroacetophenone

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled to -20°
2. 2
   workup.STIRRINGAfter stirring at -20° for 2 hours
3. 3
   Filtrationthe product filtered off
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried
6. 6
   Sonstigecrystallised from toluene

Vorschrift

2,4'-Dichloroacetophenone (0.03 mol) and 1,2,4-triazole (0.03 mol) were suspended in acetonitrile (50 ml) and cooled to -20°. Triethylamine (0.03 mol) was added dropwise with stirring. After stirring at -20° for 2 hours, the mixture was poured into water, and the product filtered off, washed with water, dried and crystallised from toluene to give pale yellow needles of 2-(1,2,4-triazol-1-yl)-4'-chloroacetophenone, m.p. 151°-3°.

Quelle