Reaktion #5423

Reaktionsgleichung

N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea

dibromoethane

potassium carbonate

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine

Ausbeute 83.1%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed by distillation
2. 2
   Extraktionthe residue was extracted with diethyl ether
3. 3
   WaschenThe extract was washed with water
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   Einengenconcentrated under reduced pressure
6. 6
   SonstigeThe residue was recrystallized from a mixture of hexane and ethanol

Vorschrift

A solution of N-(3-trifluoromethylphenyl)-N'-ethoxycarbonylthiourea (1.8 g), dibromoethane (1.29 g) and anhydrous potassium carbonate (2.6 g) in acetone (20 ml) was refluxed for 5 hours. The solvent was removed by distillation, and the residue was extracted with diethyl ether. The extract was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from a mixture of hexane and ethanol to give 1.63 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazolidine. m.p., 75.8° C.

Quelle