Reaktion #541979

ord-cba845c2ce174394ab1380830864f19b

Reaktionsgleichung

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride
→
COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314
oxycodone
Ausbeute 93.0%

Edukte

COc1ccc2c3c1O[C@H]1C(=O)CC[C@@]4(O)[C@@H](C2)N(C)CC[C@]314.Cl
Oxycodone hydrochloride

Reagenzien

Keine

Lösungsmittel

ClC(Cl)Cl
chloroform

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Waschenwashed with 5% aq. NaHCO3 (50 mL)
  2. 2
    TrocknenThe organic layer was dried over MgSO4
  3. 3
    Sonstigeevaporated
  4. 4
    SonstigeThe residue was dried in vacuo overnight

Vorschrift

Oxycodone hydrochloride (10.0 g, 28.5 mmol) was dissolved in chloroform (150 mL) and washed with 5% aq. NaHCO3 (50 mL). The organic layer was dried over MgSO4 and evaporated. The residue was dried in vacuo overnight to provide oxycodone free base (8.3 g, 93%) as a white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08497237B2uspto-grants-2013_07