Reaktion #541975

ord-c7df748c2f4f4fda951ded7921fe5f1a

Reaktionsgleichung

CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
cephalexin
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
cephalexin
N
ammonia
→
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1.O
cephalexin monohydrate

Edukte

CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
cephalexin
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1
cephalexin
N
ammonia

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Temperatur
20°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    FiltrationThe suspension was filtered through a glass
  2. 2
    Filtrationfilter
  3. 3
    Waschenthe wet cake was washed with 2×15 ml water and 2×15 ml acetone
  4. 4
    SonstigeAfter drying

Vorschrift

A crystallization reactor was filled with 20 g water and 1.0 g of cephalexin (seed). The above-mentioned acidic cephalexin solution was dosed into the crystallization reactor in 80 minutes at 30° C. The pH was kept at 5.0 with ammonia. Subsequently, the suspension was stirred at 20° C. for another 30 min. The suspension was filtered through a glass filter and the wet cake was washed with 2×15 ml water and 2×15 ml acetone. After drying, 32.6 g cephalexin monohydrate was obtained (purity ≧99.8%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08497088B2uspto-grants-2013_07