Reaktion #5419

Reaktionsgleichung

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline

tributyltin hydride

benzoyl peroxide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline

Ausbeute 75.8%

Lösungsmittel

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was removed by distillation
2. 2
   Waschenthe residue was washed with hexane
3. 3
   SonstigeRecrystallization
4. 4
   workup.ADDITIONfrom a mixture of hexane and ethanol

Vorschrift

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromothiazoline (4.7 g), tributyltin hydride (6.9 g) and a catalytic amount of benzoyl peroxide in tetrahydrofuran (100 ml) was refluxed for 10 hours. The solvent was removed by distillation, and the residue was washed with hexane. Recrystallization from a mixture of hexane and ethanol gave 2.85 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)thiazoline (Compound (xii)).

Quelle