Reaktion #5418

Reaktionsgleichung

2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline

hydrochloric acid

→

2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

Ausbeute 46.5%

Lösungsmittel

ethanol water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 3 hours
2. 2
   SonstigeEthanol was removed by distillation under reduced pressure
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   SonstigeThe solvent was removed by distillation under reduced pressure

Vorschrift

A mixture of 2-(acetylimino)-3-(3-trifluoromethylphenyl)-5-methylthiazoline (1 g) and hydrochloric acid (38 %, 4 ml) in ethanol-water (1:2, 15 ml) was refluxed for 3 hours. Ethanol was removed by distillation under reduced pressure, and the residue was neutralized with potassium carbonate, extracted with ethyl acetate and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure to give 0.4 g of 2-imino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound (xi)).

Quelle