Reaktion #54179

Reaktionsgleichung

DDQ

2,3-dihydro-6-hydroxy-7-methoxy-5-benzofurancarboxaldehyde

→

6-Hydroxy-7-methoxy-5-benzofurancarboxaldehyde

Lösungsmittel

dioxane

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 7 hours
2. 2
   Temperaturcooled
3. 3
   Sonstigethe formed solid removed by filtration
4. 4
   WaschenThe precipitate was thoroughly washed first with benzene
5. 5
   Einengenthe total concentrated in vacuo to a residue which
6. 6
   Sonstigewas chromatographed first on a 20 ml
7. 7
   Waschendry silica gel column (E. Merck 7734) with CHCl3 elution
8. 8
   Waschenelution with this solvent mixture
9. 9
   Sonstigeprovided

Vorschrift

A solution of 817 mg. (3.6 mmole) of DDQ in 10 ml. of dioxane was added to 582 mg. (3 mmole) of 2,3-dihydro-6-hydroxy-7-methoxy-5-benzofurancarboxaldehyde in 15 ml. of dioxane and the resulting mixture was heated under reflux for 7 hours, cooled and the formed solid removed by filtration. The precipitate was thoroughly washed first with benzene, then with CHCl3. The washings were combined with the initial filtrate and the total concentrated in vacuo to a residue which was chromatographed first on a 20 ml. dry silica gel column (E. Merck 7734) with CHCl3 elution followed by conventional chromatography over 20 g. of silica (E. Merck 7734) packed in benzene-ethyl acetate (95:5) and elution with this solvent mixture provided, after workup, a yellow solid, m.p. 60°-62°.

Quelle