Reaktion #54144

Reaktionsgleichung

sodium hydroxide

1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylic acid

→

sodium 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONis added
2. 2
   Sonstigeis evaporated in vacuo
3. 3
   Sonstigeisolated by vacuum filtration
4. 4
   SonstigeDrying

Vorschrift

To 5 ml of 1.0 N aqueous sodium hydroxide solution (5.0 mmoles) diluted with 50 ml of methanol is added one equivalent of 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylic acid prepared as in Example 2. After stirring for a short time the resulting slurry (pH 7-8) is evaporated in vacuo. The solid residue is slurried in ether and isolated by vacuum filtration. Drying gives a quantitative yield of sodium 1-(4-chlorophenyl)-1,6-dihydro-4-methyl-6-oxopyrimidine-5-carboxylate, m.p. >250° C.

Quelle