Reaktion #5414

Reaktionsgleichung

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromomethylthiazolidine

potassium t-butoxide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylenethiazolidine

Ausbeute 44.5%

2 -ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylenethiazolidine

Ausbeute 44.5%

Lösungsmittel

t-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
2. 2
   ExtraktionThe residue was extracted with chloroform (100 ml)
3. 3
   Waschenwashed with water
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   SonstigeAfter removal of the solvent

Vorschrift

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromomethylthiazolidine (0.7 g) and potassium t-butoxide (0.25 g) in t-butanol (30 ml) was refluxed for 5 hours, and the solvent was distilled off under reduced pressure. The residue was extracted with chloroform (100 ml), washed with water and dried over anhydrous magnesium sulfate. After removal of the solvent, the residue was subjected to column chromatography to give 0.25 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylenethiazolidine (Compound (i)).

Quelle