Reaktion #5406

Reaktionsgleichung

2-ethoxycarbonylimino-3-(3-tri-fluoromethylphenyl)-5-methylenethiazolidine

sodium methoxide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methyl-thiazoline

Ausbeute 80.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removal of the solvent under reduced pressure
2. 2
   Extraktionthe concentrated residue was extracted with chlorofom (200 ml)
3. 3
   Waschenwashed with water
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   SonstigeThe solvent was removed under reduced pressure

Vorschrift

A solution of 2-ethoxycarbonylimino-3-(3-tri-fluoromethylphenyl)-5-methylenethiazolidine (2.0 g) and sodium methoxide (28 % methanolic solution; 1.2 g) in ethanol (50 ml) was refluxed for 30 minutes. After removal of the solvent under reduced pressure, the concentrated residue was extracted with chlorofom (200 ml), washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 1.6 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methyl-thiazoline (Compound No. 1).

Quelle