Reaktion #5405

Reaktionsgleichung

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromomethylthiazolidine

potassium t-butoxide

→

2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline

Ausbeute 64.0%

Lösungsmittel

t-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter removal of the solvent under reduced pressure
2. 2
   Extraktionthe concentrated residue was extracted with chlorofom (100 ml)
3. 3
   Waschenwashed with water
4. 4
   Trocknendried over anhydrous magnesium sulfate
5. 5
   SonstigeThe solvent was removed under reduced pressure

Vorschrift

A solution of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-bromomethylthiazolidine (0.7 g) and potassium t-butoxide (0.25 g) in t-butanol (30 ml) was refluxed for 5 hours. After removal of the solvent under reduced pressure, the concentrated residue was extracted with chlorofom (100 ml), washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure, and the residue was subjected to column chromatography to give 0.36 g of 2-ethoxycarbonylimino-3-(3-trifluoromethylphenyl)-5-methylthiazoline (Compound No. 1).

Quelle