Reaktion #54045

ord-025dbd1bdd404246a45a9851709ba84b

Reaktionsgleichung

COc1ccccc1-c1ccc2c(c1)C(CSCCC(C)C)=CC(C)(C)N2
6-(2-Methoxyphenyl)-2,2-dimethyl-4-(3-methylbutylsulfanylmethyl)-1,2-dihydroquinoline
COc1ccccc1-c1ccc2c(c1)C(CBr)=CC(C)(C)N2
4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CC(C)CCS
3-methyl-1-butanethiol
→
COc1ccccc1-c1ccc2c(c1)C(CNc1ccccc1)=CC(C)(C)N2
title compound
COc1ccccc1-c1ccc2c(c1)C(CNc1ccccc1)=CC(C)(C)N2
[6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinolin-4-ylmethyl]phenylamine

Edukte

COc1ccccc1-c1ccc2c(c1)C(CSCCC(C)C)=CC(C)(C)N2
6-(2-Methoxyphenyl)-2,2-dimethyl-4-(3-methylbutylsulfanylmethyl)-1,2-dihydroquinoline
COc1ccccc1-c1ccc2c(c1)C(CBr)=CC(C)(C)N2
4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline
O=C([O-])[O-].[K+].[K+]
potassium carbonate
CC(C)CCS
3-methyl-1-butanethiol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

6-(2-Methoxyphenyl)-2,2-dimethyl-4-(3-methylbutylsulfanylmethyl)-1,2-dihydroquinoline 60 mg of 4-bromomethyl-6-(2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline, 46 mg of potassium carbonate, and 28 μL of 3-methyl-1-butanethiol reacted to give 3 mg of the title compound as a foam.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858627B2uspto-grants-2005_02