Reaktion #540285

Reaktionsgleichung

4-benzyloxybenzonitrile

KOH

→

product

Ausbeute 101.3%

4-Benzyloxybenzamide

Ausbeute 101.3%

Lösungsmittel

brine

tert-butanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe resulting reaction mixture
2. 2
   SonstigeAfter the completion of the reaction (TLC monitoring)
3. 3
   Extraktionextracted with ethyl acetate (3×50 ml)
4. 4
   TrocknenThe combined organic layer was dried over Na2SO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated under vacuum

Vorschrift

To a solution of 4-benzyloxybenzonitrile (0.61 g, 2.91 mmol) in 15 ml of tert-butanol was added fine powder of KOH (1.22 g, 21.78 mmol) and the resulting reaction mixture was refluxed for 4 h at 78° C. After the completion of the reaction (TLC monitoring), added brine solution and extracted with ethyl acetate (3×50 ml). The combined organic layer was dried over Na2SO4, filtered and concentrated under vacuum, to get the product (0.67 g) that was used as such for the next step.

Quelle