Reaktion #540163

Reaktionsgleichung

toluene

3-tert-butyl-1H-pyrazol-5-amine

triethylamine

(chloromethanetriyl)tribenzene

→

crude title compound

Ausbeute 77.8%

3-tert-butyl-N-trityl-1H-pyrazol-5-amine

Ausbeute 77.8%

Lösungsmittel

ethyl acetate

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added
2. 2
   FiltrationThe solid was filtered
3. 3
   Einengenthe filtrate was concentrated

Vorschrift

In a 20 mL vial, to a solution of 3-tert-butyl-1H-pyrazol-5-amine (150 mg, 1.078 mmol) in dichloromethane (2 mL) and triethylamine (0.180 mL, 1.293 mmol) was added (chloromethanetriyl)tribenzene (300 mg, 1.078 mmol). The reaction was stirred at 20° C. for 10 hours before toluene (5 mL) and ethyl acetate (10 mL) were added. The solid was filtered and the filtrate was concentrated to provide the crude title compound (320 mg). 1H NMR (300 MHz, DMSO-d6) δ ppm 0.95-1.02 (m, 9H) 4.82 (s, 1H) 5.75 (s, 1H) 7.15-7.37 (m, 15H) 11.13 (s, 1H); MS (DCI/NH3) m/z 382 (M+H)+.

Quelle