Reaktion #539879

ord-2364fe6aefd44f0b99b17e4e36b50ce2

Reaktionsgleichung

Sc1nnc(-c2ccc3c(c2)CCO3)o1
5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol
O=C(O)c1ccc(CCl)cc1
4-(chloromethyl)benzoic acid
O=C(O)c1ccc(CSc2nnc(-c3ccc4c(c3)CCO4)o2)cc1
title compound
Ausbeute 100.0%
O=C(O)c1ccc(CSc2nnc(-c3ccc4c(c3)CCO4)o2)cc1
4-[[[5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazol-2-yl]thio]methyl]benzoic acid
Ausbeute 100.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In the same manner as in Example 1 and using 5-(2,3-dihydro-1-benzofuran-5-yl)-1,3,4-oxadiazole-2-thiol instead of 5-(benzothiazol-6-yl)-1,3,4-oxadiazole-2-thiol and 4-(chloromethyl)benzoic acid instead of 3-(trifluoromethyl)benzyl chloride, the title compound (yield 100%) was obtained as colorless crystals.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08492378B2uspto-grants-2013_07