Reaktion #53909

ord-93bcbba6fead45e8b6bb2ff2b72ac413

Reaktionsgleichung

OCCNCCO
2-(2-Hydroxy-ethylamino)-ethanol
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride
→
CN([C@H]1CC[C@H](CCCCN(CCO)CCO)CC1)S(=O)(=O)c1ccc(C(F)(F)F)cc1
trans N-(4-{4-[Bis-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide

Edukte

OCCNCCO
2-(2-Hydroxy-ethylamino)-ethanol
CN[C@H]1CC[C@H](CCCCOS(C)(=O)=O)CC1
trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester
O=C(O)C(F)(F)F
trifluoro-acetic acid
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-trifluoromethyl-phenyl-sulfonylchloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester.trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with 2-(2-Hydroxy-ethylamino)-ethanol to give trans N-(4-{4-[Bis-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 481 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02