Reaktion #5390

Reaktionsgleichung

potassium iodide

iodine

sodium nitrite

3-amino-1-methoxynaphthalene

sulfuric acid

naphthalene

→

3-iodo-1-methoxynaphthalene

Ausbeute 18.3%

Lösungsmittel

water

water

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was heated
2. 2
   workup.STIRRINGAfter stirring for 1 hour at room temperature
3. 3
   SonstigeThe layers were separated
4. 4
   Extraktionthe aqueous portion was extracted with 3×100 mL methylene chloride
5. 5
   Waschenwas washed with 3×75 mL saturated sodium bisulfite
6. 6
   Trocknendried over anhydrous magnesium sulfate
7. 7
   Filtrationfiltered
8. 8
   Wascheneluted with hexane
9. 9
   Einengenconcentrated
10. 10
    Sonstigethe residual oil was further purified by HPLC

Vorschrift

50 g of 3-amino-1-methoxynaphthalene was added to 750 mL of 6 N sulfuric acid. The mixture was heated to dissolve the naphthalene and the resulting solution was cooled to 0° C. To the resulting slurry of amine hydrosulfate salt at 0° C. was added a solution of 20 g of sodium nitrite in 30 mL of water. The resulting mixture stirred at 0° C. for 1 hour and was then poured into a solution of 100 g of potassium iodide and 20 g of iodine in 400 mL water. After stirring for 1 hour at room temperature, 250 mL methylene chloride was added. The layers were separated and the aqueous portion was extracted with 3×100 mL methylene chloride. The organic portion was combined with the methylene chloride extracts and was washed with 3×75 mL saturated sodium bisulfite, dried over anhydrous magnesium sulfate, filtered, and stripped. The resulting product was pre-adsorbed onto silica and eluted with hexane. The appropriate fractions were combined, concentrated and the residual oil was further purified by HPLC to yield 15 g of 3-iodo-1-methoxynaphthalene as a yellow oil. The structure was confirmed by NMR.

Quelle