Reaktion #53884

ord-98da67cdf54940479d96e1e53f147d55

Reaktionsgleichung

CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1.O=C(O)C(F)(F)F
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt
O=C(Cl)Oc1cc(F)cc(F)c1
3,5-difluoro-phenyl chloroformate
CCNCCO
2-ethylamino-ethanol
→
CCN(CCO)CCCCC[C@H]1CC[C@H](N(C)C(=O)Oc2cc(F)cc(F)c2)CC1
trans-(4-{5-[Ethyl-(2-hydroxy-ethyl)-amino]-pentyl}-cyclohexyl)-methyl-carbamic acid 3,5-difluoro-phenyl ester

Edukte

CN[C@H]1CC[C@H](CCCCCOS(C)(=O)=O)CC1.O=C(O)C(F)(F)F
trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt
O=C(Cl)Oc1cc(F)cc(F)c1
3,5-difluoro-phenyl chloroformate
CCNCCO
2-ethylamino-ethanol

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt and 3,5-difluoro-phenyl chloroformate were reacted, followed by treatment with 2-ethylamino-ethanol to give trans-(4-{5-[Ethyl-(2-hydroxy-ethyl)-amino]-pentyl}-cyclohexyl)-methyl-carbamic acid 3,5-difluoro-phenyl ester, MS: 427 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02