Reaktion #538515

Reaktionsgleichung

ethyl 4-chloroacetoacetate

acetic acid

toluene

isobutylamine

→

ethyl 4-chloro-3-(isobutylamino)but-2-enecarboxylate

Ausbeute 86.0%

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAt 10° C.-30° C., with cooling
2. 2
   Sonstigethe solvent is removed under reduced pressure at temperatures of down to 35° C

Vorschrift

To a solution of 100 g of ethyl 4-chloroacetoacetate in 300 ml of toluene and 100 ml of ethanol are added 6.7 ml of acetic acid. At 10° C.-30° C., with cooling, 47.4 g of isobutylamine are added dropwise. Subsequently, the mixture is stirred at room temperature for 8 h and the solvent is removed under reduced pressure at temperatures of down to 35° C. 140.8 g of ethyl 4-chloro-3-(isobutylamino)but-2-enecarboxylate are obtained in a purity of 79% (this corresponds to 86% yield).

Quelle