Reaktion #5385

ord-6fca121f54ad4dbeb09f154726606a7f

Reaktionsgleichung

CC(=O)Oc1cc(C(=O)O)cc(OC(C)=O)c1OC(C)=O
3,4,5-Triacetoxybenzoic acid
O=C(Cl)C(=O)Cl
oxalyl chloride
CN(C)C=O
N,N-dimethylformamide
→
CC(=O)Oc1cc(C(=O)Cl)cc(OC(C)=O)c1OC(C)=O
3,4,5-triacetoxybenzoyl chloride

Edukte

CC(=O)Oc1cc(C(=O)O)cc(OC(C)=O)c1OC(C)=O
3,4,5-Triacetoxybenzoic acid
O=C(Cl)C(=O)Cl
oxalyl chloride
CN(C)C=O
N,N-dimethylformamide

Reagenzien

Keine

Lösungsmittel

ClCCl
CH2Cl2

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

3,4,5-Triacetoxybenzoic acid (296.23 g, 1 mol) was slurried in a 2 L flask in CH2Cl2 (1.0 L), and oxalyl chloride (113 mL, 1.3 mol) as added, followed by slow, dropwise addition of N,N-dimethylformamide (1.5 mL). After 2 hours at RT, gas evolution had ceased, and 3,4,5-triacetoxybenzoyl chloride was isolated by evaporation under reduced pressure.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05244763uspto-grants-1993_09