Reaktion #538457

ord-446b487ddeb148afb40c713e34567c8d

Reaktionsgleichung

Cc1ccc(S(=O)(=O)Oc2ccc(OC(F)(F)F)cc2)cc1
toluene-4-sulfonic acid 4-trifluoromethoxy-phenyl ester
C#Cc1ccc(N)cc1
4-ethynyl-phenylamine
→
Nc1ccc(C#Cc2ccc(OC(F)(F)F)cc2)cc1
4-(4-Trifluoromethoxy-phenylethynyl)-phenylamine

Edukte

Cc1ccc(S(=O)(=O)Oc2ccc(OC(F)(F)F)cc2)cc1
toluene-4-sulfonic acid 4-trifluoromethoxy-phenyl ester
C#Cc1ccc(N)cc1
4-ethynyl-phenylamine

Reagenzien

Keine

Lösungsmittel

CCCCCCC
heptane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeyield (111 mg, 80%)

Vorschrift

This product was prepared from toluene-4-sulfonic acid 4-trifluoromethoxy-phenyl ester and 4-ethynyl-phenylamine. Chromatography eluent: heptane; yield (111 mg, 80%); 1H NMR δ (CDCl3): 7.5 (d, J=8.42 Hz, 2H), 7.33 (d, J=8.60 Hz, 2H), 7.18 (d, J=8.41 Hz, 2H), 6.62 (d, J=8.62 Hz, 2H), 3.82 (s, 2H); LCMS m/z 277.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08487109B2uspto-grants-2013_07