Reaktion #53836

ord-9d9dadfec2a1402ab73e18658aa5eadf

Reaktionsgleichung

N[C@H]1CC[C@H](O)CC1
trans-4-amino-cyclohexanol
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)-benzenesulfonyl chloride
→
O=S(=O)(N[C@H]1CC[C@H](O)CC1)c1ccc(C(F)(F)F)cc1
trans-N-(4-Hydroxy-cyclohexyl)-4-trifluoromethyl-benzenesulfonamide

Edukte

N[C@H]1CC[C@H](O)CC1
trans-4-amino-cyclohexanol
O=S(=O)(Cl)c1ccc(C(F)(F)F)cc1
4-(trifluoromethyl)-benzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 11.9, trans-4-amino-cyclohexanol and 4-(trifluoromethyl)-benzenesulfonyl chloride were converted to yield trans-N-(4-Hydroxy-cyclohexyl)-4-trifluoromethyl-benzenesulfonamide as white solid, 176.2° C., MS 322 (M-H).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02