Reaktion #53835

ord-a81bdfa2584a4ca6a6aac4bba5194e6a

Reaktionsgleichung

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1
4-nitro-benzenesulfonyl chloride
→
CN([C@H]1CC[C@H](OCCCCBr)CC1)S(=O)(=O)c1ccc([N+](=O)[O-])cc1
trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-N-methyl-4-nitro-benzenesulfonamide

Edukte

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1
4-nitro-benzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 11.9, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and 4-nitro-benzenesulfonyl chloride (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-N-methyl-4-nitro-benzenesulfonamide, MS: 451 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02