Reaktion #53833

ord-7e2880f75321472e8818c7321f8dd86b

Reaktionsgleichung

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
O=S(=O)(Cl)c1ccc(F)c(F)c1
3,4-difluoro-benzenesulfonyl chloride
→
CN([C@H]1CC[C@H](OCCCCBr)CC1)S(=O)(=O)c1ccc(F)c(F)c1
trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-3,4-difluoro-N-methyl-benzenesulfonamide

Edukte

CN[C@H]1CC[C@H](OCCCCBr)CC1.Cl
trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride
O=S(=O)(Cl)c1ccc(F)c(F)c1
3,4-difluoro-benzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to example 11.9, trans-[4-(4-Bromo-butoxy)-cyclohexyl]-methyl-amine hydrochloride and 3,4-difluoro-benzenesulfonyl chloride (with 2.1 eq N,N-diisopropylethylamine) were reacted to yield trans-N-[4-(4-Bromo-butoxy)-cyclohexyl]-3,4-difluoro-N-methyl-benzenesulfonamide which was used directly in the next steps see Example 12.55-12.56 and 12.65 and 12.66.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02