Reaktion #538245

Reaktionsgleichung

2,4-dichloro-8-(4-chlorophenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine

3,3-Difluoroazetidine hydrochloride

→

2-chloro-8-(4-chlorophenyl)-4-(3,3-difluoro azetidin-1-yl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine

Ausbeute 67.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigepurified as per Preparation Ha

Vorschrift

2,4-dichloro-8-(4-chlorophenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (Preparation K) (500 mg, 1.584 mmol) and 3,3-Difluoroazetidine hydrochloride (308 mg, 2.377 mmol) were combined and purified as per Preparation Ha to give 2-chloro-8-(4-chlorophenyl)-4-(3,3-difluoro azetidin-1-yl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (400 mg, 1.075 mmol, 67.8% yield) as a white solid. LC-MS (M+H)+=372.0. 1H NMR (500 MHz, CDCl3) δ ppm 7.22-7.34 (2H, m), 7.12 (2H, d, J=8.24 Hz), 4.63-4.85 (2H, m), 4.46-4.64 (3H, m), 4.04-4.17 (1H, m), 3.91-4.04 (2H, m).

Quelle