Reaktion #53816

ord-e4b86f36f752427ca5557116cf6bb94f

Reaktionsgleichung

CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](O)CC1
trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester
BrCCCCCBr
1,5-dibromopentane
→
CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](OCCCCCBr)CC1
trans-[4-(5-Bromo-pentyloxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester

Edukte

CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](O)CC1
trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester
BrCCCCCBr
1,5-dibromopentane

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In analogy to examples 1.4 and 1.5, trans-(4-Hydroxy-cyclohexyl)-methyl-carbamic acid tert-butyl ester was reacted with 1,5-dibromopentane to yield trans-[4-(5-Bromo-pentyloxy)-cyclohexyl]-methyl-carbamic acid tert-butyl ester which was reacted with N-allylmethylamine to yield trans-(4-[5-(Allyl-methyl-amino)-pentyloxy]-cyclohexyl)-methyl-carbamic acid tert-butyl ester as white oil, MS: 369 (MH+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858651B2uspto-grants-2005_02