Reaktion #53792

ord-fdf2a18672704ebf834b4895c6e25952

Reaktionsgleichung

COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N
product
COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N
5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine
COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N
5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine
CCOP(=O)(Cc1ccc(N=C=S)cc1)OCC
product
CCOP(=O)(Cc1ccc(N=C=S)cc1)OCC
Diethyl 4-isothiocyanatobenzylphosphonate
→
CCOP(=O)(Cc1ccc(NC(=S)Nc2cc(-c3cc4cc(F)c(F)cc4[nH]3)ccc2OC)cc1)OCC
product
CCOP(=O)(Cc1ccc(NC(=S)Nc2cc(-c3cc4cc(F)c(F)cc4[nH]3)ccc2OC)cc1)OCC
(4-{3-[5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzyl)-phosphonic acid diethyl ester

Edukte

COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N
product
COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N
5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine
COc1ccc(-c2cc3cc(F)c(F)cc3[nH]2)cc1N
5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine
CCOP(=O)(Cc1ccc(N=C=S)cc1)OCC
product
CCOP(=O)(Cc1ccc(N=C=S)cc1)OCC
Diethyl 4-isothiocyanatobenzylphosphonate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine, (0.137 g, 0.5 mmol) was reacted with the product from Example 23, Step A (0.156 g, 0.54 mmol) according to the procedure for Example 23, Step B to give the product (0.172 g), mp 180-182° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858739B2uspto-grants-2005_02