Reaktion #53786

Reaktionsgleichung

HCl

1-Dodecanesulfonyl chloride

5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine

5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine

water

→

product

Ausbeute 44.9%

Dodecane-1-sulfonic acid [5-(5,6-difluoro-1H-indol-2-yl)-methoxy-phenyl]-amide

Ausbeute 44.9%

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter several hours the precipitate was filtered off
2. 2
   Waschenrinsed three times with water
3. 3
   Sonstigedried
4. 4
   SonstigeRecrystallization from ethanol

Vorschrift

1-Dodecanesulfonyl chloride (0.3 g, 1.1 mmol) was added to a stirred solution of 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl-amine from Example 3 (0.3 g, 1.11 mmol) in pyridine (3 mL) under an inert atmosphere at room temperature. After approximately 20 hours the mixture was poured into water (30 mL), stirred, and acidified with aqueous HCl. After several hours the precipitate was filtered off, rinsed three times with water, and dried. Recrystallization from ethanol afforded the product (0.25 g), mp 148-149° C.

Quelle