Reaktion #53770

Reaktionsgleichung

product

5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenylamine

5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine

3,5-dichlorophenyl isothiocyanate

→

1-(3,5-Dichloro-phenyl)-3-[5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thiourea

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated to dryness
2. 2
   Sonstigetriturated with hexanes/ethyl acetate
3. 3
   Filtrationthe insoluble solid collected by filtration (0.214 g), mp 203-205° C.

Vorschrift

The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine, (0.137 g, 0.5 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.111 g, 0.54 mmol) in ethyl acetate (10 mL) and heated briefly to 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness and triturated with hexanes/ethyl acetate, and the insoluble solid collected by filtration (0.214 g), mp 203-205° C.

Quelle