Reaktion #53767

Reaktionsgleichung

product

5-(1H-Indol-2-yl)-2-methoxy-phenylamine

5-(1H-indol-2-yl)-2-methoxy-phenylamine

3,5-dichlorophenyl isothiocyanate

→

1-(3,5-Dichloro-phenyl)-3-[5-(1H-indol-2-yl)-2-methoxy-phenyl]-thiourea

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated to dryness
2. 2
   Sonstigetriturated with hexanes
3. 3
   Filtrationthe insoluble material collected by filtration (0.169 g), mp 199-201° C.

Vorschrift

The product from Example 1, Step B, 5-(1H-indol-2-yl)-2-methoxy-phenylamine (0.1765 g, 0.74 mmol) was mixed with 3,5-dichlorophenyl isothiocyanate (0.151 g, 0.74 mmol) in ethyl acetate (20 mL) and was heated briefly at 50° C. and then allowed to stand overnight at room temperature. The reaction mixture was concentrated to dryness, triturated with hexanes, and the insoluble material collected by filtration (0.169 g), mp 199-201° C.

Quelle