Reaktion #5375

Reaktionsgleichung

2-nitro-4-acetylphenol

sodium hydroxide

sodium hydrosulfite

→

2-amino-4-acetylphenol

Ausbeute 39.1%

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added dropwise in 10 minutes
2. 2
   Sonstigeto precipitate a crystal
3. 3
   FiltrationThe crystal was filtered
4. 4
   Sonstigerecrystallized from a mixture solvent of methanol-water

Vorschrift

In a 300 ml three-neck flask, 5.00 g (27.6 m mole) of 2-nitro-4-acetylphenol and 75 ml of 2N-sodium hydroxide solution were placed. To the mixture solution, a solution, which 25.00 g of sodium hydrosulfite was dissolved in 75 ml to water, was added dropwise in 10 minutes. Then the mixture solution was stirred for 20 minutes at room temperature to precipitate a crystal. The crystal was filtered and recrystallized from a mixture solvent of methanol-water to obtain 1.63 g of 2-amino-4-acetylphenol (Yield: 39.1%).

Quelle