Reaktion #537052

Reaktionsgleichung

methyl 4-(tert-butoxy carbonylamino)-2,6-dichlorobenzoate

→

methyl 4-amino-2,6-dichlorobenzoate

Ausbeute 92.0%

Lösungsmittel

H2SO4 EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   Sonstigethe solid was collected

Vorschrift

A solution of methyl 4-(tert-butoxy carbonylamino)-2,6-dichlorobenzoate (65 g, 0.49 mol) in H2SO4/EtOAc (3 N, 20 mL) was stirred at room temperature for 2 hours. The reaction mixture was filtered, and the solid was collected to afford methyl 4-amino-2,6-dichlorobenzoate (60 g, yield: 92%). 1H NMR (DMSO-d6, 400 MHz) δ 8.40 (brs, 3H), 6.61 (s, 2H), 3.80 (s, 3H).

Quelle