Reaktion #53703

Reaktionsgleichung

tert-butyl 3-iodo-5-(2-methylsulfonylbenzenesulfonylamino)indazole-1-carboxylate

3-cyanophenylboronic acid

sodium hydrogencarbonate

→

N-[3-(3-cyanophenyl)-1 H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide

Ausbeute 3.4%

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Vorschrift

N-[3-(3-Cyanophenyl)-1H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 59 from 0.75 g of tert-butyl 3-iodo-5-(2-methylsulfonylbenzenesulfonylamino)indazole-1-carboxylate, 380 mg of 3-cyanophenylboronic acid, 30 ml of dimethylformamide, 2.85 ml of a saturated aqueous sodium hydrogencarbonate solution and 37 mg of tetrakis(triphenylphosphine)palladium[0]. 20 mg of N-[3-(3-cyanophenyl)-1 H-indazol-5-yl]-2-methylsulfonylbenzenesulfonamide are thus obtained in the form of a white solid melting at 240° C. (analysis C21H16N4O4S2.H2O % calculated C, 53.61; H, 3.86; N, 11.91; O, 17.00; S, 13.63. % found C, 53.95; H, 3.85; N, 11.68; S, 13.18).

Quelle