Reaktion #536597

Reaktionsgleichung

4-(1H-pyrazol-1-yl)aniline

phosgene

4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt

→

7-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-N-[4-(1H-pyrazol-1-yl)phenyl]-3,4-dihydroisoquinoline-2(1H)-carboxamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThis compound was prepared

Vorschrift

This compound was prepared by using procedures analogous to those described for the synthesis of Example 40 starting from 4-(1H-pyrazol-1-yl)aniline (Maybridge, Cat. #CC 18414), phosgene and 4-(4-methylpiperazin-1-yl)-6-(1,2,3,4-tetrahydroisoquinolin-7-yl)pyrimidin-2-amine HCl salt. Analytic LCMS (M+H)+: m/z=510.2.

Quelle