Reaktion #53649

Reaktionsgleichung

water

ethanol

3-iodo-5-nitro-1H-indazole

ammonia

→

5-amino-3-iodo-1H-indazole

Ausbeute 25.7%

Lösungsmittel

ethyl acetate dichloromethane

Reaktionsbedingungen

Vorschrift

5-Amino-3-iodo-1H-indazole can be obtained as described in Example 4 from 1 g of 3-iodo-5-nitro-1H-indazole, 20 ml of ethanol, 6.9 g of ferrous sulfate, 10.8 ml of distilled water and 8.2 ml of 32% aqueous ammonia. 230 mg of 5-amino-3-iodo-1H-indazole are thus obtained in the form of a yellow foam (Rf=0.12, silica gel thin layer chromatography, eluent: ethyl acetate/dichloromethane (2/8 by volume)).

Quelle