Reaktion #536

ord-c8e3d8ddd10a4c0eb4a987f93f56cea7

Reaktionsgleichung

Fc1cc(F)cc(Br)c1
Fc1cc(F)cc(Br)c1
COC(=O)c1cc(C2CCCN2)c2oc(N3CCOCC3)cc(=O)c2c1
COC(=O)c1cc(C2CCCN2)
COC(=O)c1cc(C2CCCN2c2cc(F)cc(F)c2)c2oc(N3CCOCC3)cc(=O)c2c1
COC(=O)c1cc(C2CCCN2c
Ausbeute 67.3%

Lösungsmittel

Reaktionsbedingungen

Temperatur
100°CELSIUS

Vorschrift

diacetoxypalladium (0.033 g, 0.15 mmol) was added to a stirred mixture of methyl 2-morpholino-4-oxo-8-(pyrrolidin-2-yl)-4H-chromene-6-carboxylate (1.326 g, 3.7 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (0.182 g, 0.31 mmol), 1-bromo-3,5-difluorobenzene (0.533 ml, 4.63 mmol) and cesium carbonate (1.808 g, 5.55 mmol) suspended in 1,4-dioxane (36 ml). The resulting suspension was degased with argon and then stirred at 100 °C over the WE (66hours). Albeit Lcms showed ~ 7% SM remaining, the reaction was stopped. The reaction mixture was allowed to cool to room temperature, the insolubles were removed by filtration and the filtrate concentrated. The crude product was adsorbed on silica gel and purified by flash chromatography on silica gel eluting with 2 to 5% methanol in ethyl acetate. The solvent was evaporated to dryness to afford methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate (1.172 g, 67.3 %) as a beige foam.

Quelle

750 AstraZeneca ELN dataset