Reaktion #53579

Reaktionsgleichung

4-(2,6-dichloro-4-trifluoromethylphenyl)toluene

chlorosulfonic acid

→

5-(2,6-dichloro-4-trifluoromethylphenyl)-2-methylbenzenesulfonyl chloride

Ausbeute 81.1%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGAfter further 3 hours of stirring at room temperature
2. 2
   WaschenThe organic layer was washed with water twice
3. 3
   Trocknendried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Vorschrift

6.7 g (22.0 mmol) of 4-(2,6-dichloro-4-trifluoromethylphenyl)toluene prepared in (a) was dissolved in 50 ml of chloroform, and 3.8 g (32.6 mmol) of chlorosulfonic acid was added dropwise at 0° C. with stirring. After further 3 hours of stirring at room temperature, the reaction mixture was poured into about 200 ml of ice-cold water for separation. The organic layer was washed with water twice and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 7.2 g of 5-(2,6-dichloro-4-trifluoromethylphenyl)-2-methylbenzenesulfonyl chloride (yield 81.0%).

Quelle