Reaktion #535698

Reaktionsgleichung

alpha cyclodextrin

alpha-lipoic acid

potassium hydroxide

potassium hydroxide

hydrochloric acid

→

Alpha-Lipoic Acid Alpha Cyclodextrin

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONmixed at room temperature until clear
2. 2
   workup.ADDITIONmixed until clear clear (in case of the presence of amorphous silica
3. 3
   Sonstigeto precipitate the complex
4. 4
   Sonstigedried immediately at 180° C.

Vorschrift

186.7 g of a 45% potassium hydroxide solution (1.498 moles) was added to 3910 g water and mixed at room temperature until clear. 300 g alpha-lipoic acid (99%, 1.439 moles) was added to the potassium hydroxide solution and mixed until clear clear (in case of the presence of amorphous silica as flowing agent the solution will be slightly cloudy). 1,572 g alpha cyclodextrin (at 9.25% water 1.468 moles) was added and stirred for 3 hours at room temperature until no further clarification was seen. 1.498 moles of 37% hydrochloric acid was added to precipitate the complex. With a minimal molar excess of hydrochloric acid in comparison to the potassium hydroxide used, the final pH of the solution was at pH 3. The final aqueous mixture was spray dried immediately at 180° C.

Quelle