Reaktion #53546

Reaktionsgleichung

5-Fluoro-2-(4′-amino-3′-iodophenyl)benzothiazole

copper cyanide

→

5-Fluoro-2-(4′-amino-3′-cyanophenyl)benzothiazole

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 6 hrs
2. 2
   Temperaturcooled
3. 3
   Sonstigethe solvent removed under vacuum
4. 4
   Extraktionthe product extracted with ethyl acetate (2×100 ml)
5. 5
   TrocknenThe combined extracts were dried (Na2SO4)
6. 6
   Sonstigeevaporated
7. 7
   Sonstigethe residue recrystallised from ethanol
8. 8
   Sonstigeto give a white solid

Vorschrift

5-Fluoro-2-(4′-amino-3′-iodophenyl)benzothiazole (5 g, 0.0135 mol), copper cyanide (3.65 g, 0.04 mol) and DMF (100 ml) were heated under reflux for 6 hrs, cooled and the solvent removed under vacuum. The residue was stirred in water (50 ml) for 30 mins, then the product extracted with ethyl acetate (2×100 ml). The combined extracts were dried (Na2SO4), evaporated and the residue recrystallised from ethanol to give a white solid.

Quelle