Reaktion #53531

ord-9884d58b446545b689691dcccb0c913e

Reaktionsgleichung

N=C1NC(=O)c2cc(F)c(F)cc21
5,6-difluoro-2,3-dihydro-3-imino-1H-isoindol-1-one
CN1CCC(C#N)(NC(=O)C(N)CC2CCCCC2)CC1.Cl.Cl
2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt
→
CN1CCC(C#N)(NC(=O)C(CC2CCCCC2)NC2=NC(=O)c3cc(F)c(F)cc32)CC1
title compound
CN1CCC(C#N)(NC(=O)C(CC2CCCCC2)NC2=NC(=O)c3cc(F)c(F)cc32)CC1
N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-2-(5,6-difluoro-3-oxo-3H-isoindol-1-ylamino) propionamide

Edukte

N=C1NC(=O)c2cc(F)c(F)cc21
5,6-difluoro-2,3-dihydro-3-imino-1H-isoindol-1-one
CN1CCC(C#N)(NC(=O)C(N)CC2CCCCC2)CC1.Cl.Cl
2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from 5,6-difluoro-2,3-dihydro-3-imino-1H-isoindol-1-one and 2-amino-N-(4-cyano-1-methyl-piperidin-4-yl)-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 15. MS, m/z 458.3=M+1.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06858623B2uspto-grants-2005_02