Reaktion #53528

Reaktionsgleichung

3-chloro benzo[d]isothiazole 1,1-dioxide

2-amino-N-(3-cyano-1-cyclohexyl-pyrrolidin-3-yl)-3-cyclohexyl-propionamide bis hydrochloride salt

→

title compound

N-(3-Cyano-1-cyclohexyl-pyrrolidin-3-yl)-3-cyclohexyl-2-(1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-ylamino)-propionamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas further purified by HPLC

Vorschrift

The title compound was prepared starting from 3-chloro benzo[d]isothiazole 1,1-dioxide and 2-amino-N-(3-cyano-1-cyclohexyl-pyrrolidin-3-yl)-3-cyclohexyl-propionamide bis hydrochloride salt according to the procedure from Example 10, except that the compound was further purified by HPLC using a 20×250 mm C18 reverse phase column with the method being 40% acetonitrile in water to acetonitrile. MS, m/z 512=M+1.

Quelle