Reaktion #53525

Reaktionsgleichung

3-chloro-benzo[d]isothiazole 1,1-dioxide

2-amino-N-(-4-cyano-1-propyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt

→

title compound

N-(4-Cyano-1-propyl-piperidin-4-yl)-3-cyclohexyl-2-(1,1-dioxo-1H-1λ6-benzo[d]isothiazol-3-ylamino)-propionamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas further purified by HPLC

Vorschrift

The title compound was prepared starting from 3-chloro-benzo[d]isothiazole 1,1-dioxide and 2-amino-N-(-4-cyano-1-propyl-piperidin-4-yl)-3-cyclohexylpropionamide bis hydrochloride salt according to the procedure from Example 10, except that the compound was further purified by HPLC using a 20×250 mm C18 reverse phase column with the method being 20% acetonitrile in water to acetonitrile. MS, m/z 486=M+1.

Quelle