Reaktion #534966

Reaktionsgleichung

sodium triacetoxyborohydride

diisopropylethylamine

tetrahydro-4H-pyran-4-one

4-Fluoro-6-methyl-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one

→

title compound

Ausbeute 86.4%

4-Fluoro-6-methyl-1-[1-(tetrahydro-2H-pyran-4-yl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Ausbeute 86.4%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigequenched with NaHCO3 (saturated aqueous solution)
2. 2
   workup.ADDITIONmethanol was added
3. 3
   workup.DISSOLUTIONto dissolve the solid which
4. 4
   Sonstigethe two phases were separated
5. 5
   Extraktionthe aqueous phase was extracted with dichloromethane (2×)
6. 6
   Waschenthe combined organics were washed with brine
7. 7
   Trocknendried over Na2SO4
8. 8
   Filtrationfiltered
9. 9
   Sonstigethe solvent was evaporated
10. 10
    Sonstigeto afford 3.8 g, 92%
11. 11
    SonstigeThe material was triturated with diethyl ether
12. 12
    Filtrationfiltered

Vorschrift

4-Fluoro-6-methyl-1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one (12.5 mmol, 3.6 g) (D5a) was dissolved in dichloromethane (50 ml), diisopropylethylamine (3 eq., 37.6 mmol, ˜6.4 ml), and tetrahydro-4H-pyran-4-one (4 eq., 50 mmol, ˜5 g) were added in that order at room temperature; sodium triacetoxyborohydride (3 eq., 37.6 mmol, ˜8 g) was added at room temperature and the mixture was stirred at room temperature for one overnight. The reaction mixture was diluted with dichloromethane (100 ml) and quenched with NaHCO3 (saturated aqueous solution); methanol was added to dissolve the solid which developed in the organic layer; the two phases were separated and the aqueous phase was extracted with dichloromethane (2×); the combined organics were washed with brine, dried over Na2SO4, filtered and the solvent was evaporated to afford 3.8 g, 92%. The material was triturated with diethyl ether and filtered to afford 3.6 g title compound. This was dissolved in MeOH/DCM and 2 eq of HCl (1M in Et2O) were added. The mixture was stirred at room temperature for 10 minutes, solvent was evaporated and the solid was triturated with Et2O to afford another batch, 3.8 g, pale grey solid.

Quelle